Notable natives and residents

• Dr. Jan Adams – A Harvard educated author, television star, and ground-breaking plastic surgeon, who currently practices in Beverly Hills. Jan was also the first university-trained aesthetic plastic surgeon in the United States[2]
• Todd Bell – Pro Bowl safety in the National Football League (NFL) during the 1980s. [3]
• Gay Brewer – Former American professional golfer on the PGA Tour who won the 1967 Masters Tournament
• Casey Calvert – Recently deceased guitarist for the platinum selling band Hawthorne Heights
• James E. Campbell – Democratic politician and 38th Governor of Ohio
• Butch Carter – Former player and head coach in the National Basketball Association, brother of Cris Carter
• Cris Carter – Former NFL Pro-Bowl and All-Decade player and analyst, likely first ballot hall of fame inductee, brother of Butch Carter[4]
• Dan Daub – was a 19th century Major League Baseball pitcher
• Brooklyn Decker – American fashion model who has twice appeared in the Sports Illustrated Swimsuit Edition
• Gene Garrison - World War Two veteran and author
• William H. Gross – Noted investment manager, author and prominent philatelist
• Bill Hanzlik – retired American professional basketball player and coach
• J. Eugene Harding – Successful businessman and member of the United States House of Representatives
• Thomas Howard (baseball player) – former outfielder in Major League Baseball
• Darrell Hunter – Professional American football cornerback
• Howard Jones – Renowned college football player and coach, and member of the College Football Hall of Fame's inaugural class of inductees in 1951
• July for Kings – Newly reunited band formed in Middletown, currently under contract with MCA Records
• Patrick L. Kessler – U.S. Army soldier and Medal of Honor recipient in World War II
• Frank Lickliter – is an American professional golfer. He has featured in the top 50 of the Official World Golf Rankings
• John London – longtime news reporter on WLW Television
• Jerry Lucas – Legendary National Basketball Association Hall of Famer, NBA champion, Olympic gold medalist, author, and world-renowned memory education expert. Later named one of the NBA's 50 greatest players[5]
• Donald E. “Buz” Lukens – Controversial Republican politician and former member of the United States House of Representatives
• McGuire Sisters – Vocal trio of American popular music, composed of Christine, Dorothy, and Phyllis
• Marianne Morris – former LPGA professional golfer
• Scott Nein – politician of the Republican Party, who served as a member of the Ohio Senate for two terms
• Clarence Page – Pulitzer Prize winner, journalist, syndicated columnist and member of the editorial board for the Chicago Tribune
• Susan Perkins –Miss Ohio and Miss America 1978
• Chrystee Pharris – African American television and film actress
• Raven Riley – Internet Adult Model and Entrepreneur
• Gordon Ray Roberts – Youngest living Medal of Honor recipient and the only Medal of Honor recipient still serving on active duty, has also been awarded the Silver Star, Bronze Star Medal, Presidential Unit Citation, and numerous other awards for valor and achievement
• Charlie Root – Successful Major League Baseball pitcher who holds the record for career wins for the Chicago Cubs, he also threw the pitch that Babe Ruth allegedly predicted he would hit into the seats in the 1932 World Series at Wrigley Field in Chicago
• Ed Schrock – Controversial Republican politician and former member of the United States House of Representatives
• Shepherd Sisters – Successful vocal quartet, consisting of Martha, Gayle, Judy, and Mary Lou
• Paul J. Sorg – Successful businessman and member of the United States House of Representatives
• Ferdinand Van Derveer – lawyer, Sheriff, judge and a brigadier general in the Union Army during the American Civil War
• William Verity, Jr. – U.S. administrator and steel industrialist, served as the Secretary of Commerce between 1987 and 1989 under President Ronald Reagan
• Virtue Hampton Whitted – jazz singer and bassist